Medicin in situ de produccin de Citoquinas por subpoblaciones de Linfocitos TH 1 Y TH2 en Ulceras Orales Recurrentes: Inmunomodulacion por Furoato de Mometasona

摘要

The purpose of this study was to determine the immunopathogenic mechanism(s) responsable for recurrent aphthous ulcers (RAU). In situ cytokine production was evaluated in both active and remission phases of untreated RAU and in RAU treated with Mometasone Furoate 9.1 % lotion. Clinical and histological alterations were also studied for both treatment groups. 12 patients with RAU were enrolled in a prospective, triple blind study. Each patient underwent biopsy of an untreated aphthous ulcer wich was treated with either placebo or Mometasone Furoate twice daily for 3~4 days. Specimens were analyzed immunohistochemically for ILl2, IL4, ILl O and INFgamma. Aphthae were also followed clinically. Cytokine patterns consistent with Th2 T cell predominance were found for aphthae in both acti~ ve and remission phases in placebo and mornetasone furoate treated groups. Cytokine production was decreased by aproximately 50% for both TH 1 and TH2 T cell phenotypes in the Mometasone Furoate treated ulcers, supporting its immunosupresive efect.