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Versatility of the translational machinery during stress: changing partners to keep dancing

机译:压力下转换机器的多功能性:改变伙伴以保持跳舞

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Cap-dependent translation is initiated by the binding of eIF4E to the cap structure at the 5′ end of mRNAs. During hypoxic stress, global translation decreases because eIF4E is inactivated. In a recent article in Nature, Lee and colleagues show that residual hypoxic translation is maintained by a specialized isoform of eIF4E, which binds to target mRNAs in complex with a hypoxia-induced RNP.
机译:帽依赖性翻译是通过eIF4E与mRNA 5'端的帽结构结合而开始的。在缺氧应激期间,由于eIF4E被灭活,整体翻译减少。 Lee及其同事在最近的《自然》杂志上的文章中指出,残留的低氧翻译是通过eIF4E的特异同工型维持的,该同工型与低氧诱导的RNP复合形成靶标mRNA。

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