The Synthesis of a Novel Chalcone and Evaluation for Anti-free Radical Activity and Antagonizing the Learning Impairments in Alzheimer’s Model

摘要

We synthesized a new chalcone (4,2’-dihydroxy-3methoxy-5-bromine chalcone; C) and structurally identified it via infrared spectrometry (IR), sup1/supH-NMR, mass spectrometry (MS) and element analysis (EA). C was confirmed to be highly potent in scavenging 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and OH free radicals iin vitro/i. Tests of anti-free radical activity in response to oxidative stress in mice revealed that C could elevate glutathione peroxidase (GSH-PX) and super oxide dismutase (SOD) levels and lower malonaldehyde (MDA) level in a free-radical–injured scopolamine-induced Alzheimer’s model. Further behavioral tests with the Morris water maze showed that C could antagonize the learning impairments in the Alzheimer’s model, which suggests that C has a potential role in Alzheimer’s disease.