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Overweight and obesity impair left ventricular systolic function as measured by left ventricular ejection fraction and global longitudinal strain

机译:通过左心室射血分数和整体纵向应变测量,超重和肥胖会损害左心室收缩功能

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Obesity is associated with type 2 diabetes mellitus, left ventricular diastolic dysfunction and heart failure but it is unclear to which extent it is related to left ventricular systolic dysfunction. The aim of the study was to explore the effects of overweight and obesity on left ventricular systolic function in patients with type 2 diabetes mellitus and a control group of non-diabetic persons. We prospectively investigated 384 patients with type 2 diabetes mellitus, and 184 controls who participated in the CARDIPP and CAREFUL studies. The participants were grouped according to body mass index (normal weight?
机译:肥胖与2型糖尿病,左心室舒张功能障碍和心力衰竭有关,但尚不清楚它与左心室收缩功能障碍的相关程度。该研究的目的是探讨超重和肥胖对2型糖尿病患者和非糖尿病对照组的左心室收缩功能的影响。我们前瞻性地调查了参与CARDIPP和CAREFUL研究的384例2型糖尿病患者和184例对照。根据体重指数(正常体重≤25kg / m2,超重25-29 kg / m2,肥胖≥30kg / m2)对参与者进行分组。在研究开始时和患者组4年后进行超声心动图检查。单变量和多变量回归分析显示,左心室射血分数,整体纵向应变,左心室质量和舒张功能的变化以E /é(舒张早期二尖瓣血流与环形运动速度之间的比率)表示,均与体重指数有关。体重正常的左心室射血分数和总体纵向应变值的平均值和标准差分别为57%(8%)与18.6%(2.3%),正常体重患者为53%(8%)与17.5%(超重为2.3%),肥胖者为49%(9%),而肥胖者为16.2%(3.0%)(p <0.05)与p <0.05)。对照组的相应结果分别为58%(6%)对22.3%(3.0%),55%(7%)对20.8%(3.1%)和54%(8%)对19.6。 %(4.0%)(p≤0.05,p≤0.05)。从基线到随访体重增加的患者左心室射血分数(中位数和四分位数范围)变化≥1.0(9.0)%(n?=?187),而体重减轻的患者左心室射血分数改变1.0(10.0) %(n≤179)(p≤0.05)。超重和肥胖会损害2型糖尿病患者和非糖尿病患者的左心室射血分数和整体纵向张力。试用注册ClinicalTrials.gov标识符NCT 01049737。

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