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Systemic Sarcoidosis Associated to IgA Nephropathy

机译:IgA肾病相关的全身结节病

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The sarcoidosis was rarely associated to IgA nephropathy. We report a 38-year-old man presented decreased visual acuity and xerostomia. He had two axillary lymphadenopathies and pitting edema of legs in physical examination. The ophthalmological examination revealed a right posterior uveitis. Biological investigations showed a mild renal insufficiency and elevated serum level of angiotensin-converting enzyme, β2 microglobulin and IgA. He had a proteinuria and a microscopic hematuria. The kidney echography was without abnormalities. Histological study of the renal biopsy found results in favor to IgA nephropathy. Biopsies performed in accessory salivary gland and lymph nodes revealed non-necrotising epitheloid and gigantocellular granulomatous inflammation suggesting a sarcoidosis. The diagnosis of a sarcoidosis associated to IgA nephropathy was posed. The treatment was based on oral prednisolone with gradual tapering doses. He regained normal vision. The renal function had not worsened. No relapse of sarcoidosis was noted during our follow up.
机译:结节病很少与IgA肾病相关。我们报告一个38岁的男性呈现视力下降和口干症。在体格检查中,他患有两种腋窝淋巴腺病和双腿凹坑性水​​肿。眼科检查发现右后葡萄膜炎。生物学检查显示轻度肾功能不全,血清血管紧张素转化酶,β2微球蛋白和IgA水平升高。他患有蛋白尿和镜下血尿。肾脏回波描记没有异常。肾活检的组织学研究发现,结果有利于IgA肾病。在唾液副腺和淋巴结中进行的活检显示非坏死性上皮和巨细胞肉芽肿性炎症,提示结节病。提出了与IgA肾病相关的结节病的诊断。该治疗以口服泼尼松龙为基础,剂量逐渐减小。他恢复了正常的视力。肾功能未恶化。在我们的随访中未发现结节病复发。

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