首页> 外文期刊>Cancers >Evolution of Tumor Metabolism might Reflect Carcinogenesis as a Reverse Evolution process (Dismantling of Multicellularity)
【24h】

Evolution of Tumor Metabolism might Reflect Carcinogenesis as a Reverse Evolution process (Dismantling of Multicellularity)

机译:肿瘤代谢的演变可能反映出癌变是一个逆向进化过程(多细胞性的拆除)

获取原文
获取外文期刊封面目录资料

摘要

Carcinogenesis occurs through a series of steps from normal into benign and finally malignant phenotype. This cancer evolutionary trajectory has been accompanied by similar metabolic transformation from normal metabolism into Pasteur and/or Crabtree-Effects into Warburg-Effect and finally Cannibalism and/or Lactate-Symbiosis. Due to lactate production as an end-product of glycolysis, tumor colonies acquire new phenotypes that rely on lactate as energetic fuel. Presence of Warburg-Effect indicates that some tumor cells undergo partial (if not complete) de-endosymbiosis and so cancer cells have been become unicellular microorganism (anti-Dollo's Law) specially when they evolve to develop cannibalism as way of metabolism while oxidative types of cells that rely on lactate, as their energetic fuel, might represent extra-endosymbiosis. Thus, at the end, the cancer colony could be considered as integrated metabolic ecosystem. Proper understanding of tumor metabolism will contribute to discover potential anticancer agents besides conventional chemotherapy.
机译:从正常到良性,最后到恶性表型的一系列步骤发生了癌变。这种癌症的进化轨迹伴随着类似的代谢转化,从正常代谢转变为巴斯德和/或克雷特里效应转变为沃伯格效应,最后是食人症和/或乳酸共生。由于乳酸的产生是糖酵解的最终产物,肿瘤菌落获得了新的表型,这些表型依靠乳酸作为能量的来源。 Warburg-Effect的存在表明某些肿瘤细胞经历了部分(如果不完全)去内共生作用,因此,特别是当癌细胞演变为以食人族作为新陈代谢的方式而发展为食人性时,它们已成为单细胞微生物(反Dollo定律)。依赖乳酸作为其能量的细胞可能代表了内共生。因此,最后,癌症菌落可被视为整合的代谢生态系统。对肿瘤代谢的正确理解将有助于发现除常规化疗外的潜在抗癌药。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号