首页> 外文期刊>Cancer Cell International >The zebrafish as a model for studying neuroblastoma
【24h】

The zebrafish as a model for studying neuroblastoma

机译:斑马鱼作为研究神经母细胞瘤的模型

获取原文
获取外文期刊封面目录资料

摘要

Neuroblastoma is a tumor arising in the peripheral sympathetic nervous system and is the most common cancer in childhood. Since most of the cellular and molecular mechanisms underlying neuroblastoma onset and progression remain unknown, the generation of new in vivo models might be appropriate to better dissect the peripheral sympathetic nervous system development in both physiological and disease states. This review is focused on the use of zebrafish as a suitable and innovative model to study neuroblastoma development. Here, we briefly summarize the current knowledge about zebrafish peripheral sympathetic nervous system formation, focusing on key genes and cellular pathways that play a crucial role in the differentiation of sympathetic neurons during embryonic development. In addition, we include examples of how genetic changes known to be associated with aggressive neuroblastoma can mimic this malignancy in zebrafish. Thus, we note the value of the zebrafish model in the field of neuroblastoma research, showing how it can improve our current knowledge about genes and biological pathways that contribute to malignant transformation and progression during embryonic life.
机译:神经母细胞瘤是一种在周围交感神经系统中发生的肿瘤,是儿童时期最常见的癌症。由于神经母细胞瘤发作和进展的大多数细胞和分子机制仍然未知,因此新的体内模型的产生可能适合于在生理和疾病状态下更好地解剖外周交感神经系统的发育。这篇评论的重点是使用斑马鱼作为研究神经母细胞瘤发展的合适和创新模型。在这里,我们简要总结了有关斑马鱼外周交感神经系统形成的当前知识,重点关注在胚胎发育过程中在交感神经元分化中起关键作用的关键基因和细胞途径。此外,我们还提供了一些示例,这些示例说明了已知与侵袭性神经母细胞瘤相关的遗传变化如何模仿斑马鱼的这种恶性肿瘤。因此,我们注意到斑马鱼模型在神经母细胞瘤研究领域中的价值,表明它可以如何改善我们目前在基因和生物学途径方面的知识,而这些基因和生物学途径在胚胎生命中有助于恶性转化和进展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号