Haematological, Biochemical and Microbiological Studies on Dogs Treated With 10% Erythromycin Solution

摘要

This paper aimed to evaluate the changes in erythrocytes, lymphocytes, biochemistry andmicrobiology of the intestinal flora in dogs treated with erythromycin. In the experiment, three groups ofdogs were used: a group treated with the usual dose of erythromycin, one treated with double of therecommended dose and one control treated with physiological saline. For these groups, 12 hematological,11 biochemical parameters were investigated. Microbiological investigation concerned the total number ofbacteria expressed in CFU/g feces, and sensitivity to erythromycin by diffusion method with erythromycinmicrodisks assay. The results showed no changes on erythrocyte parameters, but significant changes (p0.05) on neutrophil and lymphocyte ratio in the groups treated with erythromycin. Significant changes (p0.05) of alcanine phosphatase values were recorded, correlated to a reduction in CFU/g faeces directlyproportional to the amount of erythromycin administered. Erythromycin resistance was not detected instrains of Staphylococcus spp, Enterococcus spp. and Proteus spp., while E. coli and Pseudomonasaeruginosa had a resistance of 5.26 and 50% respectively.