THE CONSEQUENCES OF FEMALE RATS CHRONIC EXPOSURE TO LEAD ACETATE ON THE BIOMARKERS EMPHASIZING THE HORMONAL DISRUPTING POTENTIAL OF THE REPRODUCTIVE FUNCTION FOR IN VIVO EVALUATION

摘要

Lead is a metal which is naturally found in earth crust [4], in mineral from: blue lead, anglesite, cerussite, mimetit, linarit, vanadinite and wulfenite [10, 15]. The products that contain lead are: paints, accumulators, ceramics, shots, gun bullets [5, 10, 14], defense system against X rays and radiations generally [11, 13], pigments, insecticides (lead arsenate), enamels, glass [7, 11], linoleum etc. The are few data referring to lead impact on reproductive system, however, it had been underlined the fact that lead accumulation in ovaries, even less in chronic supply conditions, determines the follicle genesis disturbance, resulting less primordial follicles and more atrezic follicles and also ovary cysts. The aim of the study was to evaluate lead reproductive toxicity for female rats. The concrete objectives were: evaluation of biological markers that emphasize the hormonal disrupting potential of reproductive function for in vivo evaluation (sexual hormones: FSH, LH, estradiole, progesterone, and testosterone)