Researches Regarding the Influence of Apitherapy Diet on Number of Thrombocytes, Mean Platelet Volume and Platelet Distribution Width in Wistar Rats with CCl4 Experimentally Induced Liver Disease

摘要

The present experiment evaluates the influence of apitherapy diet on CCl4 experimentally induced liver disease in Wistar rats, by the means of number of thrombocytes, mean platelet volume and platelet distribution width. Protection was achieved by the administration of apitherapy products for three weeks. Hepatic lesion was induced by intraperitoneal injection of CCl4 (dissolved in paraffin oil, 10% solution). The experiment was unfolded on 60 Wistar rats, divided into 6 groups: control group standard food (group I), control group apitherapy diet (group II), control group apitherapy diet + royal jelly (group III), CCl4 group (group IV), group CCl4 + apitherapy diet (group V), group CCl4 + apitherapy diet + royal jelly (group VI). In comparison with group IV, the administration of apitherapy diet (group V) reveals the increase of number of thrombocytes (765.7 ? 61.07 versus 918.3 ? 63.59), the decrease of the mean platelet volume (8.32 ? 0.69 versus 7.1 ? 0.65) and the decrease of platelet distribution width (9.31 ? 1.13 versus 7.14 ? 0.7). The administration of apitherapy diet and royal jelly (group VI) determines, when compared to CCl4 group: the increase of number of thrombocytes (765.7 ? 61.07 versus 930.4 ? 7.16), the decrease of the mean platelet volume (8.32 ? 0.69 versus 6.74 ? 0.12) and the decrease of platelet distribution width (9.31 ? 1.13 versus 6.71 ? 0.15). The administration of apitherapy diet is indicated in chronic liver affection with the improvement of platelet parameters.