In Vitro Evaluation of Benzimidazole Resistance of Ancylostomidae ?i Strongylididae in Dogs

摘要

To test in vitro efficacy of Mebendazole (MBZ), Fenbendazole (FBZ) and Albendazole (ABZ) using egg hatch assay in ancilostomosis and strongyloidiasis in dogs, a number of 62 animals has been studied from Cluj-Napoca, Flore?ti, Tg. Mure?. The ante-therapeutic epidemiology survey conducted revealed that from the total number of dogs taken into the study only 41.93% received annual or biannual anthelmintic treatment. The anthelmintic medication products used were based on benzimidazole derivatives (24.19% of cases). In the case of samples collected form the dogs located in Cluj-Napoca and Flore?ti, the Mebendazole was most effective taking into account the LC50, which had the lowest value (-0.2352g/ml respectively -0.1405g/ml). However the maximum Y parameter was recorded at Fenbendazole (-1538.57 respectively -1754.82). In samples collected from dogs located in Tg. Mure? the maximum efficacy was recorded at Fenbendazole with LC50 of -0.1052g/ml and Y of -1880.42.