We report the case of a 62-year-old patient suffering from a sicca syndrome for 6 years. The diagnosis of a primary Sj?gren’s syndrome was made according to the European American study group criteria. Her mouth examination showed a fissured, smooth and left deviated tongue without evidence of atrophy or fasciculation. Neurological examination confirmed the deficit of the right XII cranial nerve and excluded other cranial nerves involvements. Cranial nerve palsy (especially optic neuritis and trigeminal palsy) is a possible neurological manifestation of Sj?gren’s syndrome. However, hypoglossal involvement is very uncommon and only two cases have been described in English literature.
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