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Reducing symptoms of major depressive disorder through a systematic training of general emotion regulation skills: protocol of a randomized controlled trial

机译:通过对一般情绪调节技能的系统培训来减轻重性抑郁症的症状:一项随机对照试验的方案

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Background Major Depressive Disorder is one of the most challenging mental health problems of our time. Although effective psychotherapeutic treatments are available, many patients fail to demonstrate clinically significant improvements. Difficulties in emotion regulation have been identified as putative risk and maintaining factors for Major Depressive Disorder. Systematically enhancing adaptive emotion regulation skills should thus help reduce depressive symptom severity. However, at this point, no study has systematically evaluated effects of increasing adaptive emotion regulation skills application on symptoms of Major Depressive Disorder. In the intended study, we aim to evaluate stand-alone effects of a group-based training explicitly and exclusively targeting general emotion regulation skills on depressive symptom severity and assess whether this training augments the outcome of subsequent individual cognitive behavioral therapy for depression. Methods/Design In the evaluation of the Affect Regulation Training, we will conduct a prospective randomized-controlled trial. Effects of the Affect Regulation Training on depressive symptom severity and outcomes of subsequent individual therapy for depression will be compared with an active, common factor based treatment and a waitlist control condition. The study sample will include 120 outpatients meeting criteria for Major Depressive Disorder. Depressive symptom severity as assessed by the Hamilton Rating Scale will serve as our primary study outcome. Secondary outcomes will include further indicators of mental health and changes in adaptive emotion regulation skills application. All outcomes will be assessed at intake and at 10 points in time over the course of the 15-month study period. Measures will include self-reports, observer ratings, momentary ecological assessments, and will be complemented in subsamples by experimental investigations and the analysis of hair steroids. Discussion If findings should support the hypothesis that enhancing regulation skills reduces symptom severity in Major Depressive Disorder, systematic emotion regulation skills training can enhance the efficacy and efficiency of current treatments for this severe and highly prevalent disorder. Trial registration This study is registered with ClinicalTrials.gov, number NCT01330485 .
机译:背景严重抑郁症是当今时代最具挑战性的心理健康问题之一。尽管可以使用有效的心理治疗方法,但许多患者未能证明临床上有明显改善。情绪调节方面的困难已被确定为重度抑郁症的假定风险和维持因素。因此,系统地增强适应性情绪调节技能应有助于降低抑郁症状的严重程度。然而,在这一点上,尚无研究系统地评估增加适应性情绪调节技能的应用对重度抑郁症症状的影响。在预期的研究中,我们旨在评估基于小组的培训的独立效果,该培训明确且专门针对抑郁症状严重程度的一般情绪调节技能,并评估该培训是否增加了后续抑郁症个体认知行为治疗的效果。方法/设计在“情感调节训练”的评估中,我们将进行一项前瞻性随机对照试验。情绪调节训练对抑郁症状严重程度和随后的个体抑郁治疗结果的影响将与基于共同因素的积极治疗和候补控制条件进行比较。研究样本将包括120名符合重度抑郁症标准的门诊病人。由汉密尔顿评定量表评估的抑郁症状严重程度将作为我们的主要研究结果。次要结果将包括心理健康的进一步指标以及适应性情绪调节技能应用的变化。在15个月的研究期内,将在摄入量和10个时间点评估所有结果。这些措施将包括自我报告,观察者评级,瞬时生态评估,并将通过实验研究和对头发类固醇的分析对子样本进行补充。讨论如果发现应支持增强调节技能可降低重度抑郁症症状严重程度的假说,则系统的情绪调节技能培训可提高这种严重且高度流行的疾病的当前治疗效果和效率。试验注册该研究已在ClinicalTrials.gov上注册,编号为NCT01330485。

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