Reduced peak oxygen uptake and implications for cardiovascular health and quality of life in patients with schizophrenia

摘要

Background Peak oxygen uptake (VO_2peak) is a strong predictor of cardiovascular disease (CVD) and all-cause mortality, but is inadequately described in patients with schizophrenia. The aim of this study was to evaluate treadmill VO_2peak, CVD risk factors and quality of life (QOL) in patients with schizophrenia (ICD-10, F20-29). Methods 33 patients, 22 men (33.7 ± 10.4 years) and 11 women (35.9 ± 11.5 years), were included. Patients VO_2peak were compared with normative VO_2peak in healthy individuals from the Nord-Tr?ndelag Health Study (HUNT). Risk factors were compared above and below the VO_2peak thresholds; 44.2 and 35.1 ml·kg-1·min-1 in men and women, respectively. Results VO_2peak was 37.1 ± 9.2 ml·kg-1·min-1 in men with schizophrenia; 74 ± 19% of normative healthy men (p 2peak was 35.6 ± 10.7 ml·kg-1·min-1 in women with schizophrenia; 89 ± 25% of normative healthy women (n.s.). Based on odds ratio patients were 28.3 (95% CI = 1.6-505.6) times more likely to have one or more CVD risk factors if they were below the VO_2peak thresholds. VO_2peak correlated with the SF-36 physical functioning (r = 0.58), general health (r = 0.53), vitality (r = 0.47), social function (r = 0.41) and physical component score (r = 0.51). Conclusion Men with schizophrenia have lower VO_2peak than the general population. Patients with the lowest VO_2peak have higher odds of having one or more risk factors for cardiovascular disease. VO_2peak should be regarded as least as important as the conventional risk factors for CVD and evaluation of VO_2peak should be incorporated in clinical practice.