Vitamin D in children with growth hormone deficiency due to pituitary stalk interruption syndrome

摘要

Recent studies have shown a relationship between vitamin D status and growth hormone (GH) and insulin-like growth factor 1 (IGF1). The objective of this study was to assess vitamin D status in children with GH deficiency due to pituitary stalk interruption syndrome (PSIS) and to investigate the relationship between 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25 (OH) 2D) serum levels and patient characteristics. A retrospective single-center study of 25OHD and 1,25(OH)2D serum concentrations in 50 children with PSIS at the initial evaluation before treatment. Mean concentrations of 33.2 ± 18.0?ng/mL for 25OHD and 74.5 ± 40.7?ng/L for 1,25(OH)2D were measured. Additionally, 25OHD concentrations were significantly higher in boys than in girls (p?=?0.04) and lower in the cold season than in the sunny season (p?=?0.03). Significant positive correlations were observed between the GH peak and serum 1,25 (OH) 2D concentrations (Rho?=?0.35; p?=?0.015) and the 1,25(OH)2D/25OHD ratio (Rho?=?0.29; p?