Optimisation of Alfuzosin Hydrochloride Organogels for Transdermal Delivery

摘要

Introduction: The purpose of present research was to prepare and optimise alfuzosin hydrochloride (AH) organogels for transdermal delivery using box-behnken design. Methods: Organogels were prepared by fluid filled fiber mechanism. In box-behnken design, the effect of gelling agent, concentration of gelling agent, apolar solvent and permeation enhancer on flux and Q₂₄ was studied. The prepared organogels were evaluated for physicochemical properties and in vitro diffusion studies, ex vivo permeation, skin irritation and stability studies. Results: All the formulations have shown better physicochemical properties. Ex-vivo skin permeation studies reveals that, Tween80 based organogel formulated using 70% w/w of Tween80, IPM as apolar solvent and Tween20 as permeation enhancer has shown maximum drug release of 89.53% for 24 hrs with flux of 33.03±0.19 μg/cm2/hr and Q₂₄ of 914.05±1.42 μg/cm2. Modified backward model was the best fit model in box-behnken design. Permeability coefficient, lag time and skin content were found to be 3.303±0.02 cm/hr, 0.45±0.30 hr and 240.66±9.89 μg/g respectively. The transdemal flux was enhanced by 8.34 times over pure drug solution. Skin irritation studies showed irritation potential of ‘0’, thus proving to be non-irritant. The formulations were stable at room temperature for 1 month. Conclusion: Results suggested that Tween80 based organogels are better carriers for transdermal delivery of AH when compared with soyalecithin and Span80: Tween80 based organogels.