Background Fluorescent molecular tomography (FMT) aims at reconstructing the spatial map of optical and fluorescence parameters from fluence measurements. Basically, solving large-scale matrix equations is computationally expensive for image reconstruction of FMT. Despite the reconstruction quality can be improved with more sources, it may result in higher computational costs for reconstruction. This article presents a novel method in the wavelet domain with rotated sources illumination. Methods We use the finite element method for the computation of the forward model. The global inverse problem is solved based on wavelet in conjunction with principal component analysis. The iterative reconstruction is implemented with sources rotated in a certain angle. The original excitation light sources are used to reconstruct the image in the first iteration. Then, upon the sources are rotated by a certain angle, they are employed for the next iteration of reconstruction. Results Simulation results demonstrate that our method can considerably reduce the time taken for the computation of inverse problem in FMT. Furthermore, the approach proposed is also shown to largely outperform the traditional method in terms of the precision of inverse solutions. Conclusions Our method has the capability to locate the inclusions. The proposed method can significantly speed up the reconstruction process with the high reconstruction quality.
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