Extremely low flow tracheal gas insufflation of helium-oxygen mixture improves gas exchange in a rabbit model of piston-type high-frequency oscillatory ventilation

摘要

Objective The purpose of this study was to show the effects of the tracheal gas insufflation (TGI) technique on gas exchange using helium-oxygen mixtures during high-frequency oscillatory ventilation (HFOV). We hypothesized that a helium-oxygen mixture delivered into the trachea using the TGI technique (0.3?L/min) would enhance gas exchange during HFOV. Methods Three rabbits were prepared and ventilated by HFOV with carrier 70% helium/oxygen or 70% nitrogen/oxygen gas mixture with TGI in a crossover study. Changing the gas mixture from nitrogen70% to helium70% and back was performed three times per animal with constant ventilation parameters. Results Compared with the nitrogen-oxygen mixture, the helium-oxygen mixture of TGI reduced PaCO₂ by 7.6?mmHg (p?2 by 14?mmHg (p? Conclusions This study demonstrated that a helium-oxygen mixture delivered into the trachea using the TGI technique would enhance CO₂ elimination and improve oxygenation during HFOV.