Sexual function improvement in association with serum leptin level elevation in patients with premature ejaculation following sertraline treatment: a preliminary observation.

摘要

Th e objective of our work was to evaluate the eff ect of sertraline hydrochloride on serum levels of leptin and sexual function in patients with premature ejaculation (PE). A total of ??? patients with a history of PE at least ? months, aged ??-?? years, were treated with sertraline hydrochloride. One hundred and four age-matched normal males without a history of PE were included control subjects and were untreated. Before and after the ? week experiment, sexual performance parameters including the intravaginal ejaculation latency time (IELT) and the Chinese premature ejaculation index (CIPE) were collected from both PE patients and control subjects through a questionnaire survey and analyzed. Serum levels of leptin were measured. Correlations of serum leptin with Body Mass Index (BMI) were analyzed. Before sertraline treatment, serum levels of leptin were signifi cantly higher (??.? vs ?.?μg/L, p?.??); and IELT and CIPE score in PE patients were increased to the values similar to those in control subjects. Th e sensitivity and specifi city values were ??.?? and ??.?? for leptin as a diagnosis target. Th ese observations suggest sertraline as a selective serotonin reuptake inhibitor may off er an eff ective option for treating premature ejaculation.