Association of dopamine receptor gene polymorphism and psychological personality traits in liability for opioid addiction.

摘要

Th ere is a clear evidence that same psychoactive substance may cause various individual physiological reactions in same environmental conditions. Although there is a general attitude on equal liability to opioid addiction, latest genetic analysis fi ndings imply there are certain quantifi - able factors that could lead to elevated individual liability towards development of opioid addiction. Th e goal of this study was to investigate association of certain personality traits and genetic factors (separately and in combination) with heroin addiction. Total of ??? individuals participated in the study: ??? patients on Metadone Maintenance Treatment (MMT) and ??? age and sex matched healthy volunteers. All were medically examined, interviewed and psychologically evaluated using Eysenck personality questionnaire (EPQ) and genotyped for DRD? (rs???????) using PCR-RFLP method. Overrepresentation of certain personality traits (neuroticism, psychoticism and extraversion/ intraversion), together with environemental risk factors such as: upbringing within incomplete families and familial history of psychotropic substances abuse, are associated with high-risk development of opioid addiction