Evaluation of endocrine changes in women with the polycystic ovary syndrome during metformin treatment

摘要

Th e aim of study was to evaluate endocrine changes in PCOS women during metformin treatment. One hundred women with PCOS, aged ??-?? years were included. A complete hormonal and metabolic pattern was recorded for each subject every ? months. Metformin treatment after ? and ?? months signifi cantly reduced weight, BMI, waist circumference, insulin and HOMA-IR (p=?.???) with high diff erences of variances within repeated measurements. Th ere was signifi cant reduction of PRL, testosterone and estradiol (p=?.???) with small diff erences within repeated measurements. Metformin did not have eff ect on TSH. However, results showed important reduction of CRP, LH, LH/FSH, androstendione, DHEA-S and progesterone (p=?.???) with moderate diff erences within measures. Metformin restored menstrual cyclicity in most participants. At baseline in study group was ??? women with oligomenorrhoea, amenorrhoea or polymenorrhoea. After ?? months of treatment, only ??? PCOS women had irregular menstrual cycle (p=?.???). Hirsutism was also reduced. Intriguingly, during fi rst ? months of treatment in PCOS women ? pregnancies occurred (p=?.???), while during last ? months treatment were ? pregnancies (p=?.???), in total ??(???). Multiple regression model revealed that the presence of anovulation in PCOS women was strongly associated with BMI, waist, FSH and age. Insulin resistance was signifi cantly predicted by BMI, cholesterol, progesterone and presence of hirsutism. Th e metformin therapy signifi cantly improved insulin resistance, imbalance of endocrine hormones, hirsutism and menstrual cyclicity in women with PCOS. Th e most important predictors for duration of metformin treatment in PCOS women were testosterone, progesterone, FSH, CRP and presence of anovulation