小剂量二甲双胍联合血府逐瘀丸对多囊卵巢综合征不孕女性糖代谢相关指标影响研究

摘要

Objective: To investigate the effect of glucose metabolism related indexes by small dose of metformin combined with the blood house of blood stasis pill in patients with polycystic ovary syndrome.Meth-ods: 82 patients with polycystic ovary syndrome in the reproductive center were selected and randomly divided into the control group (39 cases) and the experiment group (43 cases).The control group were treated by blood stasis pill and the experiment group were treated on the base of the control group with small dose met-formin.The blood glucose, sex hormone, insulin level and HOMA index were tested and compared after treat-ment.Results: Compared with before treatment,the fasting and insulin levels in two hours of administration of glucose were lower (P<0.05) ,the HOMA index were higher (P<0.05),the testosterone levels, LH and LH/FSH ratios were lower (P <0.05) ,the sex hormone binding protein were higher (P <0.05). Conclusion:Small dose of metformin combined with blood house by Yu Yu pill for women with polycystic ovary syndrome has the effect of alleviating insulin resistance, increasing the success rate of pregnancy, treatment of patients with infertility.%目的：探究小剂量二甲双胍联合血府逐瘀丸对多囊卵巢综合征所致不孕女性糖代谢相关指标的影响。方法：本研究共收集生殖中心已婚不孕的多囊卵巢综合征患者82例,采用随机数字分配法,随机分为治疗组与对照组,治疗组43例,对照组39例,对照组实施血府逐瘀丸治疗,治疗组在治疗组基础上服用小剂量二甲双胍,实验结束记录、分析以及对比两组患者血糖、性激素、胰岛素水平及 HO-MA 指数。结果：与治疗前相比,空腹和服用葡萄糖2h 的胰岛素水平下降,差异有统计学意义( P <0.05),HOMA 指数升高,差异有统计学意义,(P<0.05),睾酮水平、LH 及 LH / FSH 比值下降,差异有统计学意义,(P<0.05),性激素结合蛋白水平升高,差异有统计学意义(P<0.05)；与对照组相比,治疗组空腹和服用葡萄糖2h 的胰岛素水平较低,差异有统计学意义( P <0.05),HOMA 指数较高,差异有统计学意义(P<0.05),睾酮水平、LH 及 LH / FSH 比值较低,差异有统计学意义(P<0.05),性激素结合蛋白水平较高,差异有统计学意义(P<0.05)。结论：小剂量二甲双胍联合血府逐瘀丸对多囊卵巢综合征所致不孕女性具有缓解胰岛素拮抗,增高妊娠成功率,治疗患者不孕。