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caOmicsV: an R package for visualizing multidimensional cancer genomic data

机译:caOmicsV:R包,用于可视化多维癌症基因组数据

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Background Translational genomics research in cancers, e.g., International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), has generated large multidimensional datasets from high-throughput technologies. Data analysis at multidimensional level will greatly benefit clinical applications of genomic information in diagnosis, prognosis and therapeutics of cancers. To help, tools to effectively visualize integrated multidimensional data are important for understanding and describing the relationship between genomic variations and cancers. Results We implemented the R package, caOmicsV, to provide methods under R environment to visualize multidimensional cancer genomic data in two layouts: matrix layout and combined biological network and circular layout. Both layouts support to display sample information, gene expression (e.g., RNA and miRNA), DNA methylation, DNA copy number variations, and summarized data. A set of supplemental functions are included in the caOmicsV package to help users in generation of plot data sets from multiple genomic datasets with given gene names and sample names. Default plot methods for both layouts for easy use are also implemented. Conclusion caOmicsV package provides an easy and flexible way to visualize integrated multidimensional cancer genomic data under R environment.
机译:背景技术癌症的转化基因组学研究,例如国际癌症基因组联盟(ICGC)和癌症基因组图谱(TCGA),已经从高通量技术中产生了大型的多维数据集。多维层面的数据分析将大大有益于基因组信息在癌症的诊断,预后和治疗中的临床应用。为了提供帮助,有效地可视化集成多维数据的工具对于理解和描述基因组变异与癌症之间的关系非常重要。结果我们实施了R软件包caOmicsV,以提供在R环境下以两种布局可视化多维癌症基因组数据的方法:矩阵布局以及组合的生物网络和圆形布局。两种布局都支持显示样品信息,基因表达(例如RNA和miRNA),DNA甲基化,DNA拷贝数变异和汇总数据。 caOmicsV软件包中包含一组补充功能,以帮助用户从具有给定基因名称和样品名称的多个基因组数据集中生成绘图数据集。还实现了两种布局的默认打印方法,易于使用。结论caOmicsV软件包为在R环境下可视化集成的多维癌症基因组数据提供了一种简便灵活的方法。

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