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Risk factors associated with prevalent and incident syphilis among an HIV-infected cohort in Northeast China

机译:东北某艾滋病毒感染人群中与梅毒和梅毒相关的危险因素

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Background Sexually transmitted infections (STIs) increase HIV infectivity through local inflammatory processes. Prevalent and incident STIs among people who live with HIV/AIDS (PLWHA) are indicators of high-risk sexual behaviors and imply potential spread of HIV. Little is known about the prevalence and incidence of concurrent syphilis and associated risk behaviors among PLWHA in China. Methods A retrospective cohort study was conducted among PLWHA who attended the outpatient clinic of a designated AIDS treatment hospital in Shenyang, China, between March 2009 and May 2013. Physical examinations and syphilis serology were conducted at each visit. A questionnaire on demographic characteristics was also collected. Results 100000 copies/mL vs. ≤100000 copies/mL, aOR?=?1.56) were independent predictors for syphilis infection among PLWHA at enrollment (p?
机译:背景性传播感染(STIs)通过局部炎症过程增加了HIV的传染性。艾滋病毒/艾滋病感染者(PLWHA)中普遍发生的性传播感染和性传播感染是高危性行为的指标,暗示着艾滋病毒的潜在传播。关于中国PLWHA合并梅毒的患病率,发病率以及相关的危险行为知之甚少。方法对2009年3月至2013年5月在中国沉阳一家指定的艾滋病治疗医院门诊就诊的艾滋病病毒感染者进行回顾性队列研究。每次访视均进行体格检查和梅毒血清学检查。还收集了关于人口特征的调查表。结果入组时,PLWHA中梅毒感染的独立预测因子为100000拷贝/ mL与≤100000拷贝/ mL,aOR?=?1.56(全部p <0.05)。 Mulivariate Cox回归发现,接受ART(调整后的危险比[aHR]?=?1.81),年龄较大(≥40?岁vs.≤24?岁,aHR:5.17)和MSM状态(aHR?=?2.68)是独立的梅毒血清转化的危险因素(每个p <0.05)。结论沉阳市PLWHA梅毒患病率高。迫切需要开展一项针对PLWHA中梅毒的检测和治疗的运动,尤其是针对梅毒风险较高的MSM的运动。

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