Supplement of levosimendan to epinephrine improves initial resuscitation outcomes from asphyxial cardiac arrest

摘要

Background Levosimendan exerted favorable effects on the initial outcome in the treatment of ventricular fibrillation cardiac arrest. This study investigated the efficacy of levosimendan in the treatment of asphyxia-induced cardiac arrest in rats. Methods Animals underwent asphyxial cardiac arrest/cardiopulmonary resuscitation, randomized to three treatment groups: epinephrine (10?μg/kg) supplemented with levosimendan (bolus 12?μg/kg and infusion for 1?h, EL group); epinephrine only (10?μg/kg, E group), or levosimendan only (bolus 12?μg/kg and infusion for 1?h, L group). The resuscitation success rate, wet-to-dry ratio of lung, and rate of alveolar and blood gas analysis were recorded. Results 10 rats in the EL group, 8 in the E group, and 2 in the L group showed an initial return of spontaneous circulation ( P Conclusions In the early stage of resuscitation for asphyxia-induced cardiac arrest in rats, levosimendan supplemented with epinephrine can significantly increase coronary perfusion pressure, reduce lung injury, and ultimately enhance the survival rate.