Does Glucagon Improve Survival in a Porcine (Sus Scrofa) of Adult Asphyxial Cardiac Arrest in Addition to Standard Epinephrine Therapy

摘要

There is no difference in the rate of return to spontaneous circulation between treatment with epinephrine versus glucagon or glucagon plus epinephrine. 24 female swine 30-50kg were sedated with IV anesthesia, and instrumented (continuous aortic diastolic pressure via Millar transducer and Swan-Ganz catheter placed in pulmonary artery). Endotracheal tube was clamped. Four minutes post loss of arterial pressure, CPR was initiated via LUCAS device. We were able to create a reproducible model of asphyxia arrest. We were able to show that an active mechanical compression device (specifically LUCAS device) can provide adequate coronary perfusion pressure and there is no significant difference in CPP in relation to pig weight. We detected the ventricular fibrillation was the most common rhythm after asphyxial cardiac arrest This rhythm then degraded to asystole or bradystole.