Y chromosome of the inbred mouse KK/Ta strain is associated with reduced body size in Y-consomic strains

摘要

Background We have established 17 Y chromosome consomic (Y-consomic) mouse strains in an inbred DH/Sgn strain. In this study, based on investigations in four different genetic backgrounds, we proved that the Y chromosome of the inbred mouse KK/Ta strain is associated with reduced body size. Findings In the DH-Chr Y-+/+ background, Y chromosome substitution significantly decreased the body weight in DH-Chr Y^{KK-+/+ and DH-Chr YSJL-+/+ strains, and the DH-Chr YKK-+/+ strain was the lightest among the 17 Y-consomic strains. In the DH-Chr Y- Dh /+ background ( Dh /+ mice have skeletal malformations and are usually lighter than +/+ mice), although Y chromosome substitution did not significantly alter the body weight, the DH-Chr YKK- Dh /+ strain was the lightest among the 17 Y-consomic- Dh /+ strains. In the (B6.Cg- A y ?×?DH-Chr Y) F₁-+/+ background, Y chromosome substitution significantly decreased the body weight and length in the (B6.Cg- A y ?×?DH-Chr YKK) F₁ hybrids. In the (B6.Cg- A y ?×?DH-Chr Y) F₁- A y /+ background ( A y causes obesity and promotes linear growth), Y chromosome substitution significantly decreased body weight and length in the (B6.Cg- A y ?×?DH-Chr YKK) F₁- A y /+ hybrids. Conclusion A body-size-reducing effect of the Y chromosome of the KK/Ta mouse strain was observed irrespective of genetic background. The effect was observed in the presence of Dh and A y , the autosomal dominant mutations, both of which are known to have substantial effects on body size. These results suggest that there are Y-linked genes that control the body size in mice.}