Asthma–COPD overlap syndrome (ACOS) in primary care of four Latin America countries: the PUMA study

摘要

Background Asthma–COPD overlap syndrome (ACOS) prevalence varies depending on the studied population and definition criteria. The prevalence and clinical characteristics of ACOS in an at-risk COPD primary care population from Latin America was assessed. Methods Patients ≥40?years, current/ex-smokers and/or exposed to biomass, attending routine primary care visits completed a questionnaire and performed spirometry. COPD was defined as post-bronchodilator forced expiratory volume in 1?s/forced vital capacity (FEV₁/FVC)?1 or FVC ≥200?mL and ≥12%); ACOS was defined using a combination of COPD with the two asthma definitions. Exacerbations in the past year among the subgroups were evaluated. Results One thousand seven hundred forty three individuals completed the questionnaire, 1540 performed acceptable spirometry, 309 had COPD, 231 had prior asthma diagnosis, and 78 asthma by wheezing?+?reversibility. ACOS prevalence in the total population (by post-bronchodilator FEV₁/FVC?1/FVC?1/FVC?Conclusions ACOS prevalence in primary care varied according to definition used. ACOS by post-bronchodilator FEV₁/FVC