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Clinical monitoring of cardiac output assessed by transoesophageal echocardiography in anaesthetised dogs: a comparison with the thermodilution technique

机译:经食道超声心动图评估麻醉犬心输出量的临床监测:与热稀释技术的比较

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Cardiac output (CO) is an important haemodynamic parameter to monitor in patients during surgery. However, the majority of the techniques for measuring CO have a limited application in veterinary practice due to their invasive approach and associated complexity and risks. Transoesophageal echocardiography (TEE) is a technique used to monitor cardiac function in human patients during surgical procedures and allows CO to be measured non-invasively. This prospective clinical study aimed to compare the transoesophageal echocardiography using a transgastric view of the left ventricular outflow tract (LVOT) and the thermodilution (TD) technique for the assessment of CO during mean arterial pressure of 65–80?mmHg (normotension) and <65?mmHg (hypotension) in dogs undergoing elective surgery. Eight dogs were pre-medicated with acepromazine (0.05?mg/kg, IM), tramadol (4?mg/kg, IM) and atropine (0.03?mg/kg, IM), followed by anaesthetic induction with propofol (3–5?mg/kg IV) and maintenance with isoflurane associated with a continuous infusion rate of fentanyl (bolus of 3 μg/kg followed by 0.3?μg/kg/min). The CO was measured by TEE (COTEE) and TD (COTD) at the end of expiration during normotension and hypotension (induced by isoflurane). There was a strong positive correlation between COTEE and COTD ??(r?=?0.925; P?
机译:心输出量(CO)是重要的血液动力学参数,可在手术期间监测患者。然而,由于其侵入性方法以及相关的复杂性和风险,大多数用于测量CO的技术在兽医实践中的应用受到限制。经食道超声心动图检查(TEE)是一种用于在外科手术过程中监视人类患者心脏功能的技术,可无创地测量CO。这项前瞻性临床研究旨在比较左心室流出道(LVOT)和热稀释(TD)技术的经胃观经食道超声心动图,以评估平均动脉压在65-80?mmHg(血压正常)和<接受择期手术的狗中65?mmHg(低血压)。八只狗预先接受了乙酰丙嗪(0.05?mg / kg,IM),曲马多(4?mg / kg,IM)和阿托品(0.03?mg / kg,IM)的药物治疗,然后用异丙酚麻醉(3-5)静脉注射?mg / kg)和异氟烷维持与芬太尼的连续输注速度有关(推注3μg/ kg,然后输注0.3?μg/ kg / min)。在正常血压和低血压(由异氟烷引起)期满时,通过TEE(COTEE)和TD(COTD)测量CO。 COTEE与COTDΔε呈极强的正相关(r = 0.925; P <0.0001)。 COTD和COTEE之间的偏差为0.14?±?0.29?L / min(一致极限,?0.44至0.72?L / min)。两种方法测得的CO的百分比误差为12.32%。另外,在血压正常(r = 0.995; P <0.0001)和低血压(r = 0.78; P = 0.0223)期间,COTEE和COTD之间存在强的正相关。这项研究的结果表明,在麻醉过程中,TEE对LVOT进行透胃观察是临床上监测狗中CO的一种微创替代方法。但是,在低血压期间,尽管TEE仍然可以接受,但通过TEE获得的CO的可靠性较差。

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