Mannich base-connected syntheses mediated by ortho-quinone methides

摘要

This article provides an overview about specifically modified Mannich reactions where the process involves an ortho -quinone methide ( o -QM) intermediate. The reactions are classified on the basis of the o -QM source followed by the reactant, e.g., the dienophile partner in cycloaddition reactions (C=C or C=N dienophiles) or by the formation of multicomponent Mannich adducts. Due to the important pharmacological activities of these reactive o -QM intermediates, special attention is paid to the biological activity of these compounds.