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Low use of statins for secondary prevention in primary care: a survey in a northern Swedish population

机译:他汀类药物在初级保健中的二级预防使用率低:瑞典北部人群的一项调查

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Background Cholesterol-lowering therapy with statins is recommended in established cardiovascular disease (CVD) and should be considered for patients at high cardiovascular risk. We surveyed statin treatment before first-time myocardial infarction in clinical practice compared to current guidelines, in patients with and without known CVD in primary care clinics with general practitioners (GPs) on short-term contracts vs. permanent staff GPs. Methods A total of 931 patients (345 women) in northern Sweden were enrolled in the study between November 2009 and December 2014 and stratified by prior CVD, comprising angina pectoris, revascularisation, ischaemic stroke or transitory ischaemic attack, or peripheral artery disease. Primary care clinics were classified by the proportion of GP salaries that were paid to GPs working on short-term contracts: low (0–9?%), medium (10–39?%), or high (≥40?%). We used logistic regression to identify determinants of statin treatment. Results Among patients with prior CVD, only 34.5?% received statin treatment before myocardial infarction. The probability of statin treatment decreased with age (≥70?years OR 0.30; 95?% CI 0.13–0.66) and female gender (OR 0.39; 95?% CI 0.20–0.78) but increased in patients with diabetes (OR 3.52; 95?% CI 1.75–7.08). Among patients with prior CVD, the type of primary care clinic was not predictive of statin treatment. In the entire study cohort, 17.3?% of patients were treated with statins; women?Conclusions In patients with prior CVD we found considerable under-treatment with statins, especially among women and the elderly. Methodologies for case findings, recall, and follow-up need to be improved and implemented to reach the goals for CVD prevention in clinical practice.
机译:背景技术在已确定的心血管疾病(CVD)中,建议使用他汀类药物降低胆固醇的治疗,对于高心血管疾病风险的患者应考虑使用。与目前的指南相比,我们在首次实践性心肌梗死前对他汀类药物的治疗进行了调查,与目前的指南相比,在具有全科医生(GPs)和长期合同GP的全科医生(GPs)的初级保健诊所中,有无CVD的患者均如此。方法2009年11月至2014年12月,瑞典北部地区共有931例患者(345名女性)入组,并根据既往CVD进行分层,包括心绞痛,血运重建,缺血性中风或短暂性脑缺血发作或周围动脉疾病。初级保健诊所按支付给从事短期合同的全科医生的全科医生工资的比例分类:低(0-9%),中(10-39%)或高(≥40%)。我们使用逻辑回归来确定他汀类药物治疗的决定因素。结果在先前有CVD的患者中,只有34.5%的患者在心肌梗死前接受了他汀类药物治疗。他汀类药物治疗的可能性随着年龄的增加(≥70岁或0.30; 95%CI 0.13–0.66)和女性(OR 0.39; 95%CI 0.20–0.78)而增加,而在糖尿病患者中增加(OR 3.52; 95) ?%CI 1.75–7.08)。在先前患有CVD的患者中,初级保健诊所的类型不能预测他汀类药物的治疗。在整个研究队列中,接受他汀类药物治疗的患者为17.3%。妇女的结论在先前患有CVD的患者中,我们发现他汀类药物的治疗不足,尤其是在妇女和老年人中。病例发现,召回和随访的方法需要改进和实施,以达到临床实践中预防CVD的目标。

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