A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study

摘要

Feverfew (Tanacetum parthenium L.), magnesium and coenzyme Q10 are frequently used for migraine prophylaxis. Supplementation with a fixed combination of these three agents (Antemig?, PiLeJe) was investigated in an observational study. Adult patients suffering from migraine according to the criteria of the International Headache Society were enrolled by general practitioners (≥2 migraine attacks during previous month; exclusion of chronic migraine and medication overuse) and after a one-month baseline phase, supplemented with one tablet of 100?mg feverfew, 100?mg coenzyme Q10 and 112.5?mg magnesium per day for 3?months. Supplementation significantly reduced the number of days with migraine headache during third month of supplementation compared to baseline phase (1.3?days ±1.5 versus 4.9?days ±2.6, p?