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Role of fine needle aspiration cytology in the preoperative diagnosis of malignancy in parotid and submandibular gland neoplasm

机译:细针穿刺细胞学检查在腮腺和下颌下腺恶性肿瘤术前诊断中的作用

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Objective: To evaluate the role of Fine Needle Aspiration Cytology in the preoperative diagnosis of malignancy in parotid and submandibular gland neoplasm. Methods : This cross sectional study on 50 cases was conducted in the Department of Otolaryngology and Head-Neck Surgery of Sir Salimullah Medical College Mitford Hospital and Dhaka Medical College Hospital from January’2009 to June 2010. Results : Fine needle aspiration cytology findings of our all 50 cases were compared with postoperative histopathological reports. Out of the 50 cases, in 36(72%) cases of benign neoplasm and 7(14%) cases of malignant neoplasm, pre-operative FNAC findings and post operative histopathological findings were same. In 7 cases, FNAC and post operative histopathological findings did not matched. These were 2 (4%) false positive and 5 (10%) false negative result.In our study sensitivity of FNAC for reporting malignancy was 58.33%, specificity to rule out malignancy was 94.73% and overall accuracy in detecting malignant tumour was 86%. Positive predictive value and negative value were 77.77% and 87.80% respectively. It can be concluded that fine needle aspiration cytology is a safe, cheap and useful preoperative diagnostic tool in the diagnosis of malignancy in parotid and submandibular gland, but as fine needle aspiration cytology partly depends on operator skill, it may give false negative and false positive result. Conclusion: FNAC is a useful preoperative diagnostic tool for malignant parotid and submandibular glands with high specificity and sensitivity. DOI: http://dx.doi.org/10.3329/bjo.v19i2.17634 Bangladesh J Otorhinolaryngol 2013; 19(2): 110-118
机译:目的:评价细针穿刺细胞学检查在腮腺和下颌下腺肿瘤恶性肿瘤术前诊断中的作用。方法:从2009年1月至2010年6月,在萨利穆拉爵士医学院米特福德医院和达卡医学院附属医院的耳鼻咽喉科和头颈外科进行这项横断面研究,共50例。结果:本院的细针穿刺细胞学检查结果将所有50例病例与术后组织病理学报告进行比较。在这50例病例中,良性肿瘤36例(72%)和恶性肿瘤7例(14%)中,术前FNAC的发现和术后组织病理学的发现是相同的。在7例中,FNAC和术后组织病理学发现不匹配。假阳性结果为2(4%),假阴性结果为5(10%)。在我们的研究中,FNAC报告恶性肿瘤的敏感性为58.33%,排除恶性的特异性为94.73%,检测恶性肿瘤的总体准确性为86% 。阳性预测值和阴性值分别为77.77%和87.80%。可以得出结论,细针穿刺细胞学检查是诊断腮腺和下颌下腺恶性肿瘤的一种安全,廉价和有用的术前诊断工具,但由于细针穿刺细胞学检查在某种程度上取决于操作人员的技能,可能会导致假阴性和假阳性结果。结论:FNAC是一种有用的术前诊断工具,对腮腺和下颌下腺恶性肿瘤具有很高的特异性和敏感性。 DOI:http://dx.doi.org/10.3329/bjo.v19i2.17634 Bangladesh J Otorhinolaryngol 2013; 19(2):110-118

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