Factors Influencing the Hemodynamic and Metabolic Effects of Insulin in Muscle

摘要

Insulin mediates its own access and that of glucose to muscle by capillary recruitment and an increase in bulkblood flow. In addition, insulin resistance of muscle may result in part from an impaired hemodynamic action of insulin.The present review examines some of the factors that influence the effects of insulin both at the level of hemodynamicsand metabolism in muscle. Factors include fatty acids, the inflammatory cytokine TNF, vasodilators that relax the bloodvessels and increase bulk flow, and elevated blood pressure that may be mediated by endothelin, a potent locally releasedvasoconstrictor, or other vasoconstrictor influences.