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A methodology for direct exploitation of available information in the online model-based redesign of experiments

机译:在基于在线模型的实验重新设计中直接利用可用信息的方法

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摘要

Online model-based design of experiments techniques were proposed to exploit the progressive increase of the information resulting from the running experiment, but they currently exhibit some limitations: the redesign time points are chosen "a-priori" and the first design may be heavily affected by the initial parametric mismatch. In order to face such issues an information driven redesign optimisation (IDRO) strategy is here proposed: a robust approach is adopted and a new design criterion based on the maximisation of a target profile of dynamic information is introduced. The methodology allows determining when to redesign the experiment in an automatic way, thus guaranteeing that an acceptable increase in the information content has been achieved before proceeding with the intermediate estimation of the parameters and the subsequent redesign of the experiment The effectiveness of the new experiment design technique is demonstrated through two simulated case studies.
机译:提出了基于在线模型的实验技术设计,以利用运行中的实验所产生的信息的逐步增加,但目前它们存在一些局限性:重新设计的时间点选择为“先验”,并且第一个设计可能会受到严重影响最初的参数不匹配。为了解决这些问题,在此提出了一种信息驱动的重新设计优化(IDRO)策略:采用一种鲁棒的方法,并基于动态信息目标配置文件的最大化引入了一种新的设计准则。该方法允许确定何时以自动方式重新设计实验,从而确保在进行参数的中间估计和随后的实验重新设计之前,已经实现了可接受的信息内容增加新实验设计的有效性通过两个模拟案例研究证明了该技术。

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