Simulation of actin distribution of osteoblasts on titanium pillar arrays using a bio-chemo-mechanical model

摘要

A numerical model for the adhesion of osteoblasts on titanium micropillar structures is suggested, and a function representing the concentration level of the adhesion on the pillars is constructed based on experimental observation. The introduction of this function helps a well-known bio-chemo-mechanical model to better predict the formation of actin in osteoblasts when they are laid on arrays of titanium micro-pillars of various size attached to silicon substrate. A parameter study suggests that each pillar is associated with a different pattern of adhesion. Our finding emphasises a capability of the bio-chemo-mechanical model that it can well explain the strong influence of the boundary condition on the formation of actin within the cells.