Toxicity of Dietary Cadmium: a Review

摘要

Dietary uptake of cadmium is the most important route of uptake in humans. Uptake and retention of cadmium depend on its chemical form, certain constituents Of the diet, and detoxification by metallothioneins. Cadmium in high doses can lead To renal damage and bone demineralization in humans. In rats, cadmium induced Prostatic tumors and large granular lymphocyte leukemia. In vitro, cytotoxic con- Centrations of cadmium lead to DNA strand breaks, and induced heat shock pro- Teins and protooncogenes.