Determination of Preservatives in Finger Paints with HPLC

摘要

Two HPLC methods for the determination of 42 preservatives in finger paints are presented. With the first method mostly aromatic compounds such as parabenes, aromatic alcohols and halogenated aromatics are first extracted with methanolic formic acid and then separated and detected on a quaternary gradient HPLC-DAD-system using a phenyl-hexyl column. The second method is used for the determination of polar isothiazolinones which are extracted with aqueous formic acid and separated on a third generation C18 column. Both methods were used in interlabo-ratory tests and in a market survey and proved to be suitable for supervising future legal restrictions.