A Randomized, Double-Blind, Placebo-Controlled Trial of Combined Nevirapine and Zidovudine Compared with Nevirapine Alone in the Prevention of Perinatal Transmission of HIV in Zimbabwe

Paul Thistle14 Rachel F. Spitzer4 Richard H. Glazier56910 Richard Pilon12 Gordon Arbess511 Andrew Simor7 Eleanor Boyle111 Inam Chitsike2 Tsungai Chipato3 Maureen Gottesman511 and Michael Silverman8

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A Randomized, Double-Blind, Placebo-Controlled Trial of Combined Nevirapine and Zidovudine Compared with Nevirapine Alone in the Prevention of Perinatal Transmission of HIV in Zimbabwe

机译：奈韦拉平联合齐多夫定与单独奈韦拉平的随机，双盲，安慰剂对照试验与单独的奈韦拉平预防津巴布韦的围产期艾滋病毒传播

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Background. A single dose of nevirapine (sdNVP) administered to both mother and infant can decrease mother-to-child transmission of human immunodeficiency virus (HIV) by 47%, compared with ultra-short course zidovudine therapy (usZDV). There is limited data about the benefit of usZDV added to sdNVP to prevent mother-to-child transmission.

机译：背景。与超短疗程齐多夫定疗法（usZDV）相比，对母亲和婴儿进行单剂量的奈韦拉平（sdNVP）可以将人免疫缺陷病毒（HIV）的母婴传播减少47％。有关将usZDV的益处添加到sdNVP中以防止母婴传播的数据有限。

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《Clinical Infectious Diseases》 |2007年第1期|111-119|共9页
作者
Paul Thistle14 Rachel F. Spitzer4 Richard H. Glazier56910 Richard Pilon12 Gordon Arbess511 Andrew Simor7 Eleanor Boyle111 Inam Chitsike2 Tsungai Chipato3 Maureen Gottesman511 and Michael Silverman8;
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The Salvation Army Howard Hospital Glendale;

Departments of Paediatrics Harare Zimbabwe;

Departments of Obstetrics and Gynaecology University of Zimbabwe Harare Zimbabwe;

Departments of Obstetrics and Gynaecologyr University of Toronto;

Departments of Family and Community Medicine University of Toronto;

Departments of Public Health Sciences University of Toronto;

Departments of Laboratory Medicine and Pathobiology University of Toronto;

Departments of Lakeridge Heath Center Division of Infectious Diseases University of Toronto;

Departments of Institute for Clinical Evaluative Sciences St. Michael' Hospital Toronto;

Centre for Research on Inner City Health Toronto;

Department of Family and Community Medicine St. Michael' Hospital Toronto;

National HIV and Retrovirology Laboratories Public Health Agency of Canada Ottawa Canada;

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1. A Randomized, Double-Blind, Placebo-Controlled Trial of Combined Nevirapine and Zidovudine Compared with Nevirapine Alone in the Prevention of Perinatal Transmission of HIV in Zimbabwe [J] . Arlene C. Se?ea14 William C. Miller12 Marcia M. Hobbs13 Jane R. Schwebke67 Peter A. Leone16 Heidi Swygard1 Julius Atashili2 and Myron S. Cohen13 Clinical Infectious Diseases . 2007,第1期

机译：奈韦拉平联合齐多夫定与单独奈韦拉平的随机，双盲，安慰剂对照试验与单独的奈韦拉平预防津巴布韦的围产期艾滋病毒传播
2. Efficacy and safety of an extended nevirapine regimen in infants of breastfeeding mothers with HIV-1 infection for prevention of HIV-1 transmission (HPTN 046): 18-month results of a randomized, double-blind, placebo-controlled trial [J] . FowlerM.G., CoovadiaH., HerronC.M., JAIDS: Journal of acquired immune deficiency syndromes . 2014,第3期

机译：延长奈韦拉平方案对母乳喂养的HIV-1感染母亲的婴儿预防HIV-1传播的有效性和安全性（HPTN 046）：一项随机，双盲，安慰剂对照试验的18个月结果
3. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial. [J] . Jackson JB, Musoke P, Fleming T, The Lancet . 2003,第9387期

机译：在乌干达坎帕拉，比较产前和新生儿单剂量奈韦拉平与齐多夫定的预防母婴传播HIV-1的关系：HIVNET 012随机试验的18个月随访。
4. EFFECT OF TARGETED PULSED ELECTROMAGNETIC FIELD THERAPY ON CANINE POST-OPERATIVE HEMILAMINECTOMY: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED CLINICAL TRIAL [C] . ACVS Veterinary Symposium . 2018

机译：靶向脉冲电磁场治疗对犬术后血栓切除术的影响：双盲，随机，安慰剂对照临床试验
5. Short course zidovudine and nevirapine for prevention of mother to child transmission of HIV in Uganda: A propensity score application. [D] . Kayanja, Harriet Kose. 2005

机译：乌干达境内短期使用齐多夫定和奈韦拉平预防母婴传播艾滋病毒：倾向评分应用程序。
6. Efficacy and safety of an extended nevirapine regimen in infants of breastfeeding mothers with HIV-1 infection for prevention of HIV-1 transmission (HPTN 046): 18-month results of a randomized double-blind placebo-controlled trial [O] . Mary Glenn Fowler, Hoosen Coovadia, Casey M. Herron, -1

机译：延长奈韦拉平方案对哺乳期感染HIV-1的母亲的婴儿预防HIV-1传播的有效性和安全性（HPTN 046）：一项随机双盲安慰剂对照试验的18个月结果
7. A Randomized, Double‐Blind, Placebo‐Controlled Trial of Combined Nevirapine and Zidovudine Compared with Nevirapine Alone in the Prevention of Perinatal Transmission of HIV in Zimbabwe [O] . Paul Thistle, Rachel F. Spitzer, Richard H. Glazier, 2007

机译：单独的Nevirapine合并Nevirapine和Zidovudine的随机，双盲，安慰剂对照试验，仅在津巴布韦艾滋病毒疫苗的围产期传播中

A Randomized, Double-Blind, Placebo-Controlled Trial of Combined Nevirapine and Zidovudine Compared with Nevirapine Alone in the Prevention of Perinatal Transmission of HIV in Zimbabwe

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