Detection of gsp oncogene in growth hormone-secreting pituitary adenomas and the study of clinical characteristics of acromegalic patients with gsp-positive pituitary tumors

摘要

Conclusions Gsp mutation is one of the major intrinsic defects the pathogenesis of growth hormone- secreting pituitary tumors and the identification of gsp mutation can be a reference for classification and prog- nosis of GH tumors. Objective To investigate the incidence and clini- cal characteristics of gsp oncogene positive growth hormone-secreting adenomas of Chinese acromegalic patients. Methods Continuously 40 patients were studied. serum hormone levels of pituitary and target glands were measured and growth hormone (GH)-TRH stimu- lating tests were done before transsphenoidal or trans- frontal hypophysectomy.