Preliminary observation on the correlation between nm23 expression and Ki-67 antigen with early metastasis of human osteosarcoma

摘要

Conclusion the role of nm23 as a tumor metas- tasis suppressor in osteosarcoma is less prominent. Both nm23 and Ki-67 may help predict the possibility of early metastasis in human osteosarcomas. Objectives To detect the nm23 expression in osteosarcoma, analyze the correlation between nm23 expression a early metastasis and to study the rela- tion between nm23 expression with tumor differentiation and cell proliferation, as defined by Ki-67 labeling. Methods nm23 oncoprotein expression was measured by immunohistochemical staining using for- malin fixed, by paraffin embedded sections of 39 surgically resected osteosarcomas and was compared with Ki-67 expression, histological findings and early metastasis.