增殖细胞核抗原Ki-67与早期乳腺癌前哨淋巴结转移及分子分型表达变化的相关性研究

摘要

Objective To explore the relationship between the expression of proliferative cell nuclear antigen Ki-67 and early breast cancer with sentinel metastasis, and to analyze its correlation with the estrogen receptor (ER), progesterone receptor (PR) and HER-2 phe-notype status. Methods Fifty patients with early-stage breast cancer sentinel lymph node metastasis in our hospital were retrospectively analyzed. Compare the expression level of Ki-67 in the primary and sentinel lymph node metastases, and analyze whether the expression of Ki-67 would change the phenotype of ER, PR and HER-2. Results The expression of Ki-67 was positively correlated with tumor size (P=0.038), histological classification (P=0.020) and HER-2 expression (P=0.028). Compared with the primary lesion, Ki-67 had higher expression level in sentinel lymph node metastasis. No correlation was found between the expression of Ki-67 in the primary and sentinel lymph node metastases and the phenotypic states of ER, PR and HER-2. Conclusion High expression of Ki-67 may be a risk factor for early breast cancer metastasis to the sentinel node, but its expression changes do not affect the phenotype status of ER, PR and HER-2.%目的 探讨增殖细胞核抗原Ki-67的表达与早期乳腺癌前哨淋巴结转移之间的关系,并分析其与雌激素受体ER、孕激素受体PR及 HER-2 表型状态之间的相关性.方法 回顾性分析2016-2018年收治的50例早期乳腺癌前哨淋巴结转移患者的资料,比较原发灶与前哨淋巴结转移灶中Ki-67的表达水平,并分析Ki-67的表达是否会改变ER、PR、HER-2的表型状态.结果 Ki-67表达与患者肿瘤大小(P=0.038)、组织学分级(P=0.020)及HER-2表达(P=0.028)呈正相关;与原发灶相比,Ki-67在前哨淋巴结转移灶中表达水平更高;原发灶和前哨淋巴结转移灶中Ki-67的表达水平与ER、PR、HER-2的表型状态无相关性.结论 Ki-67高表达可能是促进早期乳腺癌向前哨淋巴结转移的危险因素,但其表达水平并不影响ER、PR、HER-2的表型状态.