Induction of immune tolerance in adult rabbits undergoing heterotopic cardiac transplantation

摘要

Conclusion This report may provide the experi- mental basis for inducing immune tolerance in clinical transplantation. Objective To induce experimental immune tole- rance in rabbits and observe its effects on heterotopic cardiac transplantation. Methods Donor's splenic lymphocytes pre- treated with platinum metal chelator were injected into the recipient's mesenteric-portal vein. Cyclosporin A was perfused through the donor's heart. Results The injection of donor's splenic lympho- cytes before transplantation could significantly prolog the survival time f the heterotopically transplanted heart.