Healing effects of heparin on acetic acid-induced gastric ulcers in rats

摘要

Conclusions Heparin with the doses used in the present study accelerated the healing of acetic acid-in- duced gastric ulcers n rats in a dose-and time-depen- dent manner, and this action was related to its effects to increase the levels of gastric mucosal PGE_2 and GMBF as well as to decrease the gastric mucosal MPO activity. Objective To investigate whether or not heparin can accelerate the healing process s of acetic acid-in- duced gastric ulcers in rats and to identify the mecha- nisms for heparin to produce this effect, so that we can develop a new therapeutic application to heparin be- sides its traditional anticoagulant activity.