Analysis and use of bcl-2/IgH gene rearrangement in non-Hodgkin's lymphoma

Chen Yan; Xiang Zhifu; Li Yuying

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Analysis and use of bcl-2/IgH gene rearrangement in non-Hodgkin's lymphoma

机译：非霍奇金淋巴瘤中bcl-2 / IgH基因重排的分析及应用

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Bcl-2/IgH gene rearrangement are mainly associated with low-grade B-cell NHL. The pattern of bcl-2 rearrangement is MBR-IgH. The detection of bcl-2 rearrangement by PCR provides a sensitive and specific assay of minimal residual diease(MRD). It helps to improve staging of disease, stratification and evaluation of treatment.

机译：Bcl-2 / IgH基因重排主要与低级B细胞NHL相关。 bcl-2重排的模式是MBR-IgH。通过PCR检测bcl-2重排提供了灵敏且特异的最小残留酶（MRD）检测方法。它有助于改善疾病的分期，分层和治疗评估。

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《Chinese Medical Journal》 |1999年第8期|p.730-730|共1页
作者
Chen Yan; Xiang Zhifu; Li Yuying;
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正文语种 eng
中图分类医药、卫生;
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1. Heteroduplex analysis of VDJ amplified segments from rearranged IgH genes for clonality assessments in B-cell non-Hodgkin's lymphoma. A comparison between different strategies | Haematologica [J] . M Gonzalez, D Gonzalez, R Lopez-Perez, Haematologica . 1999,第9期

机译：对来自重排的IgH基因的VDJ扩增片段进行异源双链分析，以评估B细胞非霍奇金淋巴瘤的克隆性。不同策略之间的比较|血液学
2. Novel diagnostic biomarker for patients with Non-Hodgkin's Lymphoma by IgH gene rearrangement [J] . Jian Bo, Lu Sun, Wenqing Wang, Journal of Cancer Research and Therapeutics . 2016,第2期

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3. Evaluation diagnostic usefulness of immunoglobulin light chains (Igκ, Igλ) and incomplete IGH D-J clonal gene rearrangements in patients with B-cell non-Hodgkin lymphomas using BIOMED-2 protocol. [J] . S Ghorbian, I Jahanzad, G R Javadi, Clinical & translational oncology : . 2014,第11期

机译：使用BIOMED-2协议评估免疫球蛋白轻链（Igκ，Igλ）和不完整的IGH D-J克隆基因重排在B细胞非霍奇金淋巴瘤患者中的诊断价值。
4. Robust Diagnosis of Non-Hodgkin Lymphoma Phenotypes Validated on Gene Expression Data fromDifferent Laboratories [C] . Gyan Bhanot, Gabriela Alex International Workshop on Bioinformatics and Systems Biology . 2005

机译：从Drifferent Laboratories的基因表达数据验证的非霍奇金淋巴瘤表型的鲁棒诊断
5. Fluorescence in situ hybridization (FISH) and risk factors for non-Hodgkin lymphoma (NHL) subtypes defined by t(14;18) translocations and bcl-2 expression. [D] . Chang, Cindy Ma. 2007

机译：荧光原位杂交（FISH）和非霍奇金淋巴瘤（NHL）亚型的危险因素，定义为t（14; 18）易位和bcl-2表达。
6. IgH gene rearrangements as plasma biomarkers in Non-Hodgkins Lymphoma patients [O] . Jian He, Jian Wu, Yuchen Jiao, 2011

机译：IgH基因重排作为非霍奇金淋巴瘤患者血浆生物标志物
7. Cytometric detection of DNA amplified with fluorescent primers: applications to analysis of clonal bcl-2 and IgH gene rearrangements in malignant lymphomas [O] . RL Barker, CA Worth, SC Peiper 1994

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8. Mouse Monoclonal Antibody Specific for an Allotypic Determinant of the Igh(a) Allele of Murine IgM: Genetic and Functional Analysis of Igh-6a Epitopes Using Anti-IgM Monoclonal Antibodies. [R] . Sieckmann, D. G., Stall, A. M., Subbarao, B. 1991

机译：小鼠单克隆抗体特异性针对Igh（a）小鼠Igm等位基因的同种型决定因素：使用抗Igm单克隆抗体的Igh-6a表位的遗传和功能分析。

Analysis and use of bcl-2/IgH gene rearrangement in non-Hodgkin's lymphoma

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