RELATIONSHIP BETWEEN SOME HUMORAL FACTORS AND LEFT VENTRICULAR HYPERTROPHY IN ESSENTIAL HYPERTENSION

摘要

Objective. To evaluate the relationship between certain humoral factors and left ventricular hypertrophy (LVH) in essential hypertension. Patients and Methods. 62 essential hypertension (EH) patients (32 men, 30 women; mean age, 55 years) and 20 normotensive healthy subjects (10 men, 10 women; mean age, 52 years) were studied. EH patients were divided into LVH group and non-LVH group by echocardiography. After an overnight fast, blood samples were taken for the determination of parathyroid hormone (PTH), angiotensin Ⅱ (AT Ⅱ) and aldosterone (ALD) by radioimmunoassay. Results. There was a significant difference in PTH、 AT Ⅱ and ALD between the EH group and control group. Furthermore, in LVH group PTH, AT Ⅱ and ALD elevated significantly as compared with non-LVH group. In addition, we found that LVMI (left ventricular mass index) correlated with ATⅡ (r = 0.342, P < 0.01) and ALD (r = 0.356, P < 0.01). There was a more significant correlation between LVMI and PTH (r = 0.422, P < 0.0025). Conclusions. Some humoral factors are important determinants of LV mass. Besides the renin-angiotensin-aldosterone system, PTH might play an important role in cardiac hypertrophy.