A NEW METHOD OF EARLY DIAGNOSIS OF FAT EMBOLISM SYNDROME: AN EXPERIMENTAL STUDY OF THE PULMONARY MICROVASCULAR CYTOLOGY

摘要

Fat embolism syndrome (FES) is a severe complication of traumatic, extremity bone fracture. Zenk-er first described the presence of fat droplets in the lungs of a patient who died following a crush injury to the chest and abdoman (in 1862). The first clinical diagnosis of fat embolism was made by Von Bergman (in 1873), Gurd and Wilson advanced clinically diagnostic criteria: the presence of one major feature, four minor features and fat macroglobulinaemia in 1970 and 1974. A diagnosis of FES made on the basis of respiratory changes alone has also been advocated (Lindequen in 1987). Chestre and Bannier suggested bronchoalveolar lavege for rapid diagnosis of the fat embolism syndrome in trauma patients (in 1990 and 1992). Recently, many authors have obtained some progress on early diagnosis, but there is still lack of special method for the diagnosis of FES. The aim of our study is to investigate character and early diagnostic method of FES at subclinical stage.