The Effect of calmodulin antagonist berbaminederivative-EBB on hepatoma in vitro and in vivo

摘要

Conclusions The CaM antagonist, EBB, has a strong anti-hepatorma effect and enhances the effect of 5- FU, induces hepatoma cell to apoptosis, promoters the P53 protein expression and decreases the amount of CaM in the cytoplasm. All these results demonstrate that EBB is a new and potentially useful drug against Hepatoma and should be researched further. Objective To evaluate the anti-hepatoma effect of Calmodulin antagonist 0-4-ethoxyl-butyl-Berbamine (EBB), one of berbamine derivatives. Methods Monotetrazolium(MTT)method was used to analyzed the effect of EBB on the proliferation and Growth inhibition effect.