Down stream involvement of the bile duct in hepatolithiasis

摘要

Conclusions The obvious mucosal lesions associated with hepatholithiasis were located down-stream of the bile duct, predominantly in the hilar region(73/100 of mucosal lesions). The proliferative activity of examined bile duct mucosa lesions increased with the development of pathological deterioration, which may contribute to the development of hilar bile duct stricture and hilar cholangiocarcinoma. Objective To evaluate the down strream involvement of the bile duct in hepatolithiasis. Methods Mechanical damage to bile duct epithelia and long standing cholangitis as result of hepatolithiasis Play an important in the carcinogenesis of bile duct epithelia and stricture of the intra-and extra-hepatic Bile duct.