Effect of Dachengqi Granules on Level of Endotoxin in Enterogenous Endotoxemia in Rats

摘要

Objective: To study the effect of Dachengqi Granule (DCQG) on endotoxin level in rats of enterogenous endotoxemia. Methods: Enterogenous endotoxemia model of rats was made by peritoneal injection of E. coli. In the treated groups, the rats were treated with different doses of DCQG, cefaclor and DCQG plus cefaclor respectively, starting from 3 days before to 1 day after modeling. Endotoxin levels in plasma, urine and stool were determined and compared. Results: Except for the cefaclor group, the plasma and urine endotoxin levels in the treated groups were lower significantly (P<0.05), while the endotoxin level in stool was obviously higher than that in the untreated model group. Conclusion: DCQG has the intestinal barrier protective effect including anti-bacteria, anti-inflammation and clearing endotoxin.